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On Dec. 17, 2021, the IRS issued Notice 22-03, which contains the 2022 standard mileage rates used to calculate the deductible costs of operating an automobile for business, charitable, medical, or moving purposes. The agency said it rates the standard mileage for business use based on an annual study of the fixed and variable costs of operation. According to the IRS, standard mileage rates are up slightly from 2021 in two categories.